John P. O'Reilly, PhD
Department of Biological Sciences
Southeastern Louisiana University
Hammond, Louisiana 70402
Tel: (985) 549.3536
Fax: (985) 549.3851
1997 Ph.D., Neurobiology, Department of Biology, Yale University, New Haven, CT
Thesis Title: Hypoxia in the Central Nervous System:
Electrophysiologic Responses and the Role of Na+ Channels.
1994 M.Phil., Department of Biology, Yale University, New Haven, CT
1993 M.S., Department of Biology, Yale University, New Haven, CT
1977 B.A., Biology, University of Virginia, Charlottesville,VA
2008 present Associate Professor, Southeastern Louisiana University, Hammond, LA
2003 2008Assistant Professor, Southeastern Louisiana University, Hammond, LA
Teaching - Neurobiology with lab (undergraduate and graduate), Animal Behavior with lab (undergraduate
and graduate), Animal Physiology with lab (undergraduate), Anatomy & Physiology lecture & laboratory
(undergraduate), General Biology laboratory (undergraduate), Biology of Sensory Systems (graduate),
Physiology of Homeostasis (graduate).
Research - structure-function analysis of slow inactivation in voltage-gated Na+ channels (Navs).
PREVIOUS RESEARCH EXPERIENCE
1997 2002Postdoctoral Research Fellow, Department of Anesthesia Research, Brigham & Women's
Hospital, Harvard Medical School, Boston, MA
Research focused on understanding the relationship between molecular structure and physiologic function in
voltage-gated sodium channels (Navs) using wild-type, chimeric and mutant Navs from different species and tissues.
1991 1997Graduate Studies, Departments of
Biology, Neurobiology, Physiology, and Pediatrics
Yale University and Yale Medical School, New Haven, CT
Electrophysiologic analysis of the response of neurons in the central nervous system to oxygen deprivation
(hypoxia) which included the role of regional variations, age-related differences, and other intrinsic and extrinsic
factors. Studies in other laboratories included restriction mapping of olfactory-associated genes in Drosophila,
histological studies on muscle morphogenesis in Drosophila, physiological studies of fever-induced temperature
regulation in rats, and neuropharmacologic studies on synaptogenesis in frog.
1987 1991Research Associate, Department of
Biomedical Engineering, Johns Hopkins Medical School,
Neuroanatomical and neurophysiological studies of the rat autonomic nervous system using neuroanatomical
tracing, light and immunfluorescent microscopy, and in vivo neurophysiologic recordings
1983 1986Research Associate, Department of Anatomy,
Georgetown University Medical School,
Comparative neuroanatomical studies of the VIIIth cranial nerve in fish and salamanders.
Southeastern Louisiana University, Hammond, LA
2008 present Associate Professor, Department of Biological Sciences
2003 2008 Assistant Professor, Department of Biological Sciences
Neurobiology with lab (undergraduate and graduate) once per year
Animal Behavior with lab (undergraduate and graduate) once per year
Animal Physiology with lab (undergraduate) three terms
Anatomy & Physiology lecture & laboratory (undergraduate) every semester
General Biology laboratory (undergraduate) every few years
Biology of Sensory Systems (graduate) every other year
Physiology of Homeostasis (graduate) every other year
Northeastern University, Boston, MA
2002 (2 terms)Invited Lecturer, Neurophysiology, Physician Assistant Program
2000 2002 (4 terms) Instructor, Anatomy & Physiology, Department of Biology
1999 (1 term) Instructor, General Biology for non-majors, Department of Biology
Yale University, New Haven, CT
1995 1996 (2 terms) Lecturer, Laboratory for Neurobiology (graduate & undergraduate)
1994 1995 (2 terms) Teaching Assistant, Laboratory for Biology of Reproduction and Development
1992 1994 (3 terms) Teaching Assistant, Neurobiology (lecture & laboratory, graduate & undergraduate)
1991 1992 (2 terms) Teaching Assistant, Lecture & Laboratory for Introduction to Biology (for majors)
GRANTS AND FELLOWSHIPS
2008 2011Academic Research Enhancement Award (R15-AREA), National Institutes of Health, $186,895
2005 2008Academic Research Enhancement Award (R15-AREA), National Institutes of Health, $179,092
2008 2009 Faculty Development Grant, Southeastern Louisiana University, $2000
2007 2008 Faculty Development Grant, Southeastern Louisiana University, $2000
2006 2007 Faculty Development Grant, Southeastern Louisiana University, $1000
2005 2006 Faculty Development Grant, Southeastern Louisiana University, $1862
2004 2005 Faculty Development Grant, Southeastern Louisiana University, $1800
2000 2003National Research Service Award, National Institutes of Health, $126,844
1999 2000Postdoctoral Fellowship, American Heart Association, New England Affiliate, $50,000
PROFESSIONAL AFFILIATIONS & ACTIVITIES
Society for Neuroscience
American Association for the Advancement of Science
Invited Reviewer, Journal of Neuorphysiology
Invited Reviewer, Experimental Brain Research
Invited Reviewer, Neuroscience Letters
Invited Reviewer, Pflugers Archives - European Journal of Physiology
Invited Reviewer, Forensic Science International
Invited Reviewer, Biophysical Journal
Invited Reviewer, Journal of Physiology (London)
Invited Reviewer, Biochimica et Biophysica Acta - Biomembranes
Selected Peer-reviewed Research Articles
Chancey JW, Shockett PE, O'Reilly JP (2007) Relative resistance to slow inactivation of human cardiacNa+ channel hNav1.5 is reversed by lysine or glutamine substitution at V930 in D2-S6. American Journal ofPhysiology Cell Physiology 293: C1895-C1905. PMID: 17928536
O'Reilly JP, Shockett PE (2006) Slow-inactivation induced conformational change in domain 2-segment 6 of cardiacNa+ channel. Biochemical and Biophysical Research Communications 345: 59-66. PMID: 16674915
O'Reilly JP, Wang S-Y, Wang GK (2003) Methanethiosulfonate-modification alters local anesthetic block inrNav1.4 cysteine-substituted mutants S1276C and L1280C. Journal of Membrane Biology. 193: 47-56. PMID:12879165
O'Reilly JP, Wang S-Y, Wang GK (2001) Residue-specific effects on slow inactivation at V787 in D2-S6 of Nav1.4sodium channels. Biophysical Journal 81: 2100-2111. PMID: 11566781
Novotny EJ, Ariyan C, Mason GF, O'Reilly JP, Haddad GG, Behar KL (2001) Differential increases in cerebral corticalglucose metabolism during rat postnatal development is greater in vivo than in vitro. Brain Research 888: 193-202.PMID: 11150475
O'Reilly JP, Wang S-Y, Wang GK (2000) A point mutation in domain 4 - segment 6 of rat skeletal muscle Na+channel produces an atypical inactivation state. Biophysical Journal 78: 773-784. PMID: 10653790
Xia Y, Fung M, O'Reilly JP, Haddad GG (2000) Increased neuronal excitability after long-term O2 deprivation ismediated mainly by sodium channels. Brain Research: Molecular Brain Research 76(2):211-219. PMID:10762696
O'Reilly JP, Wang S-Y, Kallen RG, Wang GK (1999) Comparison of slow inactivation in human heart and rat skeletalmuscle Na+ channel chimeras. Journal of Physiology (London) 515.1: 61-73. PMID: 9925878
O'Reilly JP, Cummins TR, Haddad GG (1997) Oxygen deprivation inhibits Na+ current in hippocampal neurons viaprotein kinase C. Journal of Physiology (London) 503.3: 479-488. PMID: 9379405
O'Reilly JP, Haddad GG (1996) Chronic hypoxia in vivo renders neocortical neurons more vulnerable to subsequentacute hypoxic stress. Brain Research 711: 203-210. PMID: 8680864
O'Reilly JP, Jiang C, Haddad GG (1995) Major differences in response to graded hypoxia between hypoglossal and neocortical neurons. Brain Research 683: 179-186. PMID: 7552353
Selected Published Abstracts and Presentations
O'Reilly JP, Shockett PE, Chancey JW (2009) Structure-function analysis of slow inactivation in voltage-gated Na+channels. Louisiana Academy of Sciences meeting.
Chancey JW, Shockett PE, O'Reilly JP (2007) Lysine substitution at V930 in D2-S6 of hNav1.5 greatly enhancesslow inactivation. 2007 Biophysical Society Meeting Abstracts. Biophysical Journal Supplement, 20a, 473-Pos.
O'Reilly JP, Wang S-Y, Wang GK (2002) MTSEA-modification of L1280C in D3-S6 of rNav1.4 produces resistanceto local anesthetic block similar to lysine-substitution in L1280K. Abstracts: Society for Neuroscience 835.5.
O'Reilly JP, Wang S-Y, Wang GK (2001) Different amino acids at V787 in D2-S6 of rat skeletal muscle Na channelproduce opposite effects on slow inactivation. Biophysical Society Abstract 692.
O'Reilly JP, Wang S-Y, Wang GK (1999) Altered kinetics with single and double mutations in segment 6 of muscle Nachannel. Biophysical Society Abstract 497.
O'Reilly JP, Wang S-Y, Wang GK (1998) Na channel slow
inactivation differs between human heart and rat
skeletalmuscle isoforms. Abstracts: Society for Neuroscience
O'Reilly JP, Haddad GG (1996) Hypoxia reduces Na+ current in hippocampal neurons via a kinase mediated pathway.Abstracts: Society for Neuroscience 841.1.
O'Reilly JP, Schwartz ML, Haddad GG (1995) Adaptive mechanisms in developing brain: II. Effect of chronic hypoxiaon neuronal excitability. Annals of Neurology 38: 533.
Novotny EJ, Ariyan C, Akiyama Y, O'Reilly JP, Behar KL, Haddad GG (1995) Comparison of the ontogeny of brainoxidative metabolism in vivo vs in vitro: an NMR spectroscopy study. Abstracts: Society for Neuroscience 656.6.
O'Reilly JP, Haddad GG (1995) Different responses of cortical and brain stem neurons to graded hypoxia. AmericanJournal of Respiratory and Critical Care Medicine 151(4): A633.51